Sequelae of Thorotrast.

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Coarctation of the aorta and other late sequelae of administration of thorium dioxide (thorotrast).

Coarctation of the aorta secondary to a cervicomediastinal thorotrastoma developed in a 30-year-old man 25 years after carotid arteriography. Other local manifestations of the thorotrastoma included occlusion of the left common carotid artery and partial occlusion of the left vertebral and left subelavian arteries, bilateral recurrent laryngeal nerve paresis, periesophageal adhesions, and multi...

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Long-term hazards of Thorotrast.

As regards changes which could lead to irreversible lowering of cardiac function, the arteritis might prove in the long run the most significant if it progressed. There is no evidence in the affected vessels of obstructive phenomena at the time of the patient's death and no effects on the myocardium were noted. It would seem reasonable to infer that if this necrotizing arteritis was a manifesta...

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Lung fibrosis induced by Thorotrast.

A 63 year old woman developed progressive shortness of breath, pulmonary hypertension, and respiratory failure and died from pulmonary fibrosis 45 years after thoracic fistulography with Thorotrast. Bouts of acute respiratory failure occurred with features of noncardiogenic pulmonary oedema. Lung tissue obtained by biopsy and at necropsy showed abundant radioactive particles of thorium dioxide ...

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Thyroid disease following the administration of thorotrast.

Four cases of thyrotoxicosis are reported among 35 patients who had been given Thorotrast during the investigation of intracranial haemorrhage. For the group as a whole Thorotrast had been given between 11 and 31 years (mean 23.4 years) before this study. Thyrotoxicosis occurred in four patients between six and 17 years (mean 11.8 years) after the injection of Thorotrast. The fact that thyrotox...

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Thorotrast toxicity: the safety of gadolinium compounds.

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ژورنال

عنوان ژورنال: BMJ

سال: 1965

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.5469.1062-d